From Iraq:
Increased galanin-galanin receptor 1 signaling, inflammation, and insulin resistance are associated with affective symptoms and chronic fatigue syndrome due to long COVID
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0316373
From the latest Science for ME weekly update
@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
#MEcfs
(Australia-wide survey)
Are you someone who is experiencing, treating or caring for someone with ME/CFS and/or #LongCovid ?
"The Australian e-Health Research Centre at CSIRO ... is conducting a survey to understand the research priorities of the community"
Link:
https://csiro.qualtrics.com/jfe/form/SV_50apVQ5MHXTReBw
@mecfs
#MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #PwME @longcovid
#PASC #PwLC #postcovid #postcovid19 #LC #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
@auscovid19 #auscovid19
1/
"We know that infection and reinfection, even when mild, is linked to cell and organ damage that may harm their future health. More needs to be done to protect our children, and the first step is ensuring that our schools are safe"
"The briefing also says Long Covid can also lead to a 'substantially increased' risk of sudden death and 'silent' damage to cells and organs which can lead to later illness.
"Certainly the silent organ damage is a real problem, we think, for future development of disease."
https://www.rnz.co.nz/news/national/543885/long-covid-warning-silent-organ-damage-is-a-real-problem
3/
"Some are so severely ill that they have completely lost their previous lives," says Stallmach. So far, no convincing therapy has been found for this either. "But I am optimistic that this will change in the next few years."
#LongCovid #PASC @longcovid @covid19 @novid@chirp.social @novid@a.gup.pe
Sympathetic article; quotes 3 German experts
"Years after the pandemic, has the threat of #LongCovid subsided?"
https://www.yahoo.com/news/years-pandemic-threat-long-covid-153323420.html
Includes this "Depending on the symptoms, doctors will often recommend exercise therapy ..." but then that can be true for people without PEM
@longcovid
#PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
@covid19 #Coronavirus
#COVID19 #COVID #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver
1/
"shows in people with T2D, poorer glycemic control with HbA1c≥8% increases the risk of developing #LongCOVID after #COVID19 infection, specifically with respiratory symptoms & brain fog"
https://drc.bmj.com/content/13/1/e004536
Screenshot from Science for ME weekly update
Hashtags:
@longcovid
#PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
@covid19 #Coronavirus
#COVID #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver
@auscovid19 #auscovid19
"There are over 200 different symptoms that can appear in any different combination. And then the other piece about it is there are about six different mechanisms of what can be causing long COVID. So everyone has in common COVID as the thing that started their long COVID.
However, there are so many different physiological things going wrong in different people with long COVID, they might require different treatments."
"There are actually a lot of great trials going on [...] one looking at mitochondrial dysfunction is Rapamycin, which David Petrino’s group is running."
"There’s a few looking at immunomodulation with JAK inhibitors, both the Baricitinib trial by Wes Eli’s group and another JAK inhibitor trial that’s starting at Harvard. Another immunomodulation option is IVIG, which is being run by the NIH RECOVER consortium. This one’s tricky because it’s not super scalable. You have to get the antibodies from people and then infuse them into other people"
"And then the other mechanism that’s being looked at a lot now is viral persistence, both through a few different monoclonal antibodies trials– Michael Peluso’s, funded by the Patient Led Research Collaborative. Nancy Klimas is just starting one funded by the Schmidt Initiative for Long COVID and the state of California. And then there’s another one in Italy that’s funded by industry, all looking at monoclonal antibodies. And then the last viral persistence one is also being run by the Petrino group on Truvada, which is an HIV antiviral."
Terrifying Numbers for Long Covid
Year 3 numbers:
"Here we built a cohort of 135,161 people with SARS-CoV-2 infection and 5,206,835 controls from the US Department of Veterans Affairs who were followed for 3 years to estimate risks of death and PASC.
Among non-hospitalized individuals, the increased risk of death was no longer present after the first year of infection, and risk of incident PASC declined over the 3 years but still contributed 9.6 (95% confidence interval (CI): 0.4–18.7) disability-adjusted life years (DALYs) per 1,000 persons in the third year.
Among hospitalized individuals, risk of death declined but remained significantly elevated in the third year after infection (incidence rate ratio: 1.29 (95% CI: 1.19–1.40)).
Risk of incident PASC declined over the 3 years, but substantial residual risk remained in the third year, leading to 90.0 (95% CI: 55.2–124.8) DALYs per 1,000 persons.
Altogether, our findings show reduction of risks over time, but the burden of mortality and health loss remains high in the third year among hospitalized individual"
Terrifying Numbers for Long Covid
PASC Prevalence (Long Covid):
By quartiles of a year:
"Based on different assessment or follow-up timepoints after acute COVID-19 infection, PCS prevalence estimated at ≥ 3rd, ≥ 6th, and ≥ 12th months timepoints were each 45.06% (95% CI: 41.25–48.87%), 41.30% (95% CI: 34.37–48.24%), and 41.32% (95% CI: 39.27–43.37%), respectively."
By region:
"Based on continental regions, pooled PCS prevalence was estimated at 46.28% (95% CI: 39.53%-53.03%) in Europe, 46.29% (95% CI: 35.82%-56.77%) in America, 49.79% (95% CI: 30.05%-69.54%) in Asia, and 42.41% (95% CI: 0.00%-90.06%) in Australia."
By the two year point:
"This meta-analysis shows the presence of post-COVID symptoms in 30% of patients two-years after COVID-19. Fatigue, cognitive disorders, and pain were the most prevalent post-COVID symptoms. Psychological disturbances as well as sleep problems were still present two-years after COVID-19."
https://www.journalofinfection.com/article/S0163-4453(23)00590-X/fulltext
https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-024-19264-5 [bmcpublichealth.biomedcentral.com]
New from Spain:
SARS-CoV-2 Viral Load and Cytokine Dynamics Profile as Early Signatures of Long COVID Condition in Hospitalized Individuals
https://onlinelibrary.wiley.com/doi/10.1111/irv.70068
Image is from latest Science for ME weekly update
@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver
@auscovid19 #auscovid19
![SARS-CoV-2 Viral Load and Cytokine Dynamics Profile as Early Signatures of Long COVID Condition in Hospitalized Individuals — Jacobo Alonso Domínguez et al.
"our study provides an early signature that highlights the different profiles in [viral load] and cytokine dynamics from the onset of infection and the following weeks between individuals who develop long COVID and those who do not."](https://assets.disabled.social/media_attachments/files/113/857/467/998/466/512/original/645c753a51795c20.png "SARS-CoV-2 Viral Load and Cytokine Dynamics Profile as Early Signatures of Long COVID Condition in Hospitalized Individuals — Jacobo Alonso Domínguez et al.
\"our study provides an early signature that highlights the different profiles in [viral load] and cytokine dynamics from the onset of infection and the following weeks between individuals who develop long COVID and those who do not.\"")
New from Germany:
Neurological post-COVID syndrome is associated with substantial impairment of verbal short-term and working memory
https://www.nature.com/articles/s41598-025-85919-x
Image is from latest Science for ME weekly update
@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver
@auscovid19 #auscovid19
"Meet the Americans who still take COVID-19 precautions seriously"
Image is from latest Science for ME weekly update
@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver
@auscovid19 #auscovid19
@chronicillness
@spoonies
@disability
#neisvoid
#chronicillness
#chroniclife
Das Risiko für #LongCovid (engl. #pasc ) steigt neuen Studien zufolge offenbar tatsächlich mit jeder weiteren Infektion: https://www.thelancet.com/journals/lanam/article/PIIS2667-193X(24)00311-9/fulltext
Geschätztes Risiko für Long Covid nach einer Infektion liegt bei 16,7 % (weniger bei geimpften Personen, höher bei schwerem Verlauf), das Risiko steigt signifikant auf 30,8 % nach mehreren Infektionen...
Bitte schützt euch und eure Lieben mit #Maske in Innenräumen wenigstens während der (teils mehrfachen) jährlichen Covid-Wellen.
#CovidIsNotOver
3/
The NIH have sent out a press release. Hopefully this will lead to a lot of coverage.
"NIH-funded study finds cases of ME/CFS increase following SARS-CoV-2"
#MEcfs #LongCovid
@mecfs @longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver
@auscovid19 #auscovid19
2/
Blog post on this study "#COVID19 Triggers ME/CFS" by Suzanne D. Vernon, PhD
https://batemanhornecenter.org/covid-19-triggers-me-cfs/
"531 participants met ME/CFS criteria, translating to a prevalence of 4.5% among those infected—nearly 8 times higher than uninfected participants"
@mecfs #MyalgicEncephalomyelitis #MEcfs #CFS #PwME @longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #longhaulers #COVIDBrain #NeuroPASC
@covid19 #Coronavirus
#COVID #COVID_19 #COVIDー19 #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe #auscovid19
New US research
Incidence & Prevalence of Post‑COVID‑19 Myalgic Encephalomyelitis:A Report from the Observational
RECOVER‑Adult Study
https://link.springer.com/article/10.1007/s11606-024-09290-9
"ME/CFS is a diagnosable sequela that develops at an increased rate following SARS-CoV-2 infection"
@mecfs
#MyalgicEncephalomyelitis #MEcfs #CFS #PwME @longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #longhaulers #COVIDBrain
@covid19 #Coronavirus
#COVID19 #COVID #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver
@auscovid19
On Monday 3 February, Post Covid Network Nederland and the Radboud Center for Philosophy and Society are hosting a workshop on Post-COVID ethics. The main language of the event is English.
"Are you, or is someone you love, living with long Covid symptoms? We want to hear about your experience.
- How is it impacting your life?
- Do you feel that you are receiving appropriate supports?
- Have you come out the other side of it?"
https://www.thejournal.ie/long-covid-readers-stories-6582898-Dec2024
Hashtags:
@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
4/
"In this opinion article we highlight intrinsic mitochondrial dysfunction, endothelial abnormalities, and a muscle fiber type shift towards a more glycolytic phenotype as main contributors to the reduced exercise capacity in long COVID."
New:
2024 Update of the RECOVER-Adult Long COVID Research Index
https://jamanetwork.com/journals/jama/fullarticle/2828329
@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver
@auscovid19 #auscovid19
